European Network for the Investigation of Gender Incongruence

The European Network for the Investigation of Gender Incongruence (ENIGI) is a prospective, observational, longitudinal, multicenter study. Nowadays, the ENIGI study is divided into ENIGI psychology part and ENIGI endocrinology part. The first participant for the ENIGI Endocrinology study was included in Ghent in 2010. Measurements are performed at baseline (start of hormonal treatment), during the first year (three months, six months, twelve months), after two, three, and five years.

The ENIGI Endocrinology study is designed to investigate the effects and side-effects of hormonal treatment in trans people. By performing a multicenter study, a larger study population could be achieved and results were more generalizable.